HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 868351Generated: October 31, 2026
Malonic Acid → 3-(4-Phenyl-3-pyridyl)acrylic acid
https://huagongshe.com/reaction/868351
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-Phenylpyridine-3-carbaldehyde | HCID 13160544 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 3-(4-Phenyl-3-pyridyl)acrylic acid | HCID 53917538 | 64.3% |
Reaction Steps
A mixture of 4.3 g of 4-phenyl-3-pyridinecarbaldehyde [cf. Heterocycles, 14, 813 (1980)], 2.5 g of malonic acid, 0.5 ml of piperidine, and 6 ml of pyridine is stirred at 100° C. for 2 hours. After cooling, 50 ml of diethyl ether is added, and the resulting precipitate is collected. The obtained solid is washed with water and dried to give 3.4 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04778796 |
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| Source dataset | uspto-grants-1988_10 |
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| ORD ID | ord-f1e2ee7d3787457791a3e82c719d748a |
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| Source note | uspto-grants-1988_10 |
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