Sodium Hydroxide → HCID 53841523, compound

HRID 868356Notes

Reaction equation

HRID 868356 reaction equation
[C:1]([O:5][C:6]([C:8]1[CH:9]=[CH:10][C:11]([CH:14]=[CH:15][C:16]([O:18]CC)=[O:17])=[N:12][CH:13]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>C(O)C>[C:1]([O:5][C:6]([C:8]1[CH:9]=[CH:10][C:11]([CH:14]=[CH:15][C:16]([OH:18])=[O:17])=[N:12][CH:13]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54176212HCID 54176212, compound

Product 1

HCID 53841523HCID 53841523, compoundYield 57.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2.5 g of ethyl 3-(5-t-butoxycarbonyl-2-pyridyl)acrylate, 12 ml of 1N sodium hydroxide solution, and 6 ml of ethanol is stirred at room temperature for 5 hours. The ethanol is distilled off below 40° C. under reduced pressure, and the aqueous solution is adjusted to pH 4.5 with 10% hydrochloric acid. The resulting precipitate is collected and washed with cold water to give 1.3 g of the title compound.

Workup

  1. distillationThe ethanol is distilled off below 40° C. under reduced pressure
  2. customThe resulting precipitate is collected
  3. washwashed with cold water

Sources & evidence

ORD record
ord-a1b3135e83b64fd78def43beb2f82335
Source dataset
uspto-grants-1988_10
Patent number
US04778796

Reaction notes

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