Sodium Hydroxide → HCID 53841523, compound

Participants

Reaction Steps

A mixture of 2.5 g of ethyl 3-(5-t-butoxycarbonyl-2-pyridyl)acrylate, 12 ml of 1N sodium hydroxide solution, and 6 ml of ethanol is stirred at room temperature for 5 hours. The ethanol is distilled off below 40° C. under reduced pressure, and the aqueous solution is adjusted to pH 4.5 with 10% hydrochloric acid. The resulting precipitate is collected and washed with cold water to give 1.3 g of the title compound.

Provenance & Evidence