反应详情

To a suspension of 10.0 g of pyridoxal hydrochloride in 400 ml of ethanol, 17.2 g of (carbethoxymethylene)triphenylphosphorane is added under cooling in an ice-water bath, and the mixture is stirred at room temperature for 17 hours. The reaction mixture is concentrated to half in volume and cooled in an ice-water bath. The precipitate is collected and washed with a small amount of cold ethanol to give 3.2 g of ethyl 3-(3-hydroxy-5-hydroxymethyl-2-methyl-4-pyridyl)acrylate hydrochloride.

1. additionis added
2. temperatureunder cooling in an ice-water bath
3. concentrationThe reaction mixture is concentrated to half in volume
4. temperaturecooled in an ice-water bath
5. customThe precipitate is collected
6. washwashed with a small amount of cold ethanol