反应详情

温度

50 °C

4-Methoxy-3-nitrobenzotrifluoride (95 g) in isopropanol (1.0 liter) and water (250 ml) was mixed with concentrated hydrochloric acid (15 ml). Iron powder (180 g) was added and the mixture was heated and stirred under reflux. After 90 minutes the mixture was cooled to 50° C. and filtered. The residue was washed with isopropanol and the combined filtrates evaporated. The residue was dissolved in toluene and the solution dried (MgSO4) and evaporated. The residue was triturated with light petroleum (b.p. 30°-40°) to give the 3-amino-4-methoxybenzotrifluoride as a colourless solid (68 g).

1. temperaturethe mixture was heated
2. temperatureunder reflux
3. filtrationfiltered
4. washThe residue was washed with isopropanol
5. customthe combined filtrates evaporated
6. dissolutionThe residue was dissolved in toluene
7. dry with materialthe solution dried (MgSO4)
8. customevaporated
9. customThe residue was triturated with light petroleum (b.p. 30°-40°)