Perchloric Acid → HCID 14257763, compound

HRID 868418Notes

Reaction equation

HRID 868418 reaction equation
[CH2:1]([N:8]1[CH2:15][CH:14]2[C:16](=[O:17])[CH:10]([CH2:11][Se:12][CH2:13]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl(O)(=O)(=O)=[O:19]>C1C=CC=CC=1>[CH2:1]([N:8]1[CH2:15][CH:14]2[C:16]([OH:19])([OH:17])[CH:10]([CH2:11][Se:12][CH2:13]2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 24247Perchloric AcidHCID 14257719HCID 14257719, compound

Product 1

HCID 14257763HCID 14257763, compoundYield 90.2%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

7-Benzyl-3-selena-7-azabicyclo[3.3.1]nonan-9-one (0.65 g, 2.2 mmol) was dissolved in dry benzene (250 mL). Perchloric acid (60%, 1.0 g, 6.0 mmol) was added dropwise very slowly with cooling and swirling. This pecipitated an orange solid which adhered to the side of the flask. The benzene was decanted and the solid was recrystallized (95% ethanol) to give 7-benzyl-3-selena-7-azabicyclo[3.3.1]nonan-9,9-diol hydroperchlorate (0.62 g, 68.3%) as white needles: mp 214.0°-216.0° C. (dec); IR (KBr) cm-1 3430, 1080; 1H NMR (DMSO-d6) δ2.43 [br s, 2H, H(2,4)ax ], 2.72 [br d, 2H, H(2,4)eq ], 3.22-3.50 [m, 6H, H(6,8)ax, H(1,5), OH], 3.50-3.64 [m, 2H, H(6,8)eq ], 4.35 [d, 2H, H(10-NCH2)], 7.40-7.70 [m, 5H, ArH], 9.20 [br s, 1H, H(7)]; 13C NMR (DMSO-d6) ppm 21.1 [C(2,4)], 34.7 [C(1,5)], 54.9 [C(6,8)], 60.1 [C(10)-NCH2)], 92.5 [C(9)], 129.2, 129.7, 130.0, 130.5 [ArC]; 15N NMR (DMSO-d6) ppm 51.88 [N(7)]; 77Se NMR (DMSO-d6) ppm 62.39 [Se(3)]. Analysis calculated for C14H20NClSeO6 : N, 3.39; Se, 19.13. Found: N, 3.20; Se, 19.51. ##STR29##

Workup

  1. temperaturewith cooling
  2. customThe benzene was decanted
  3. customthe solid was recrystallized (95% ethanol)

Sources & evidence

ORD record
ord-1a4a27ebf6e042bdb0bec22b3b02bc92
Source dataset
uspto-grants-1988_10
Patent number
US04778892

Reaction notes

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