Methyl Isocyanate → HCID 86742489, compound

HRID 868450Notes

Reaction equation

HRID 868450 reaction equation
[P:1]([O-:46])([O:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][N+:42]([CH3:45])([CH3:44])[CH3:43])([O:3][CH2:4][CH:5]([OH:26])[CH2:6][O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[O:2].[CH3:47][N:48]=[C:49]=[O:50]>C(N(CC)CC)C>[P:1]([O-:46])([O:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][N+:42]([CH3:45])([CH3:44])[CH3:43])([O:3][CH2:4][CH:5]([O:26][C:49](=[O:50])[NH:48][CH3:47])[CH2:6][O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[O:2]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 14376332HCID 14376332, compound

Product 1

HCID 86742489HCID 86742489, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

By following the procedure of Example 8, 661 mg of the alcohol derivative obtained in Example 25 was reacted with 2 ml of methyl isocyanate and 1 ml of triethylamine to give 485 mg (yield: 68%) of the desired product.

Sources & evidence

ORD record
ord-47dc22850f0a4aeea1fee8e4ddee6640
Source dataset
uspto-grants-1988_10
Patent number
US04778912

Reaction notes

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