HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → HCID 21287074, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | 4-Chloro-3-methylphenol | HCID 1732 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 5-Fluoro-2-nitrobenzoic acid methyl ester | HCID 5152049 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 21287074 | HCID 21287074 | — |
Reaction Steps
Methyl 5-fluoro-2-nitrobenzoate was reacted with the sodium salt of 4-chloro-3-methylphenol (prepared from sodium hydride and the phenol) in dimethylformamide at 100° C. for 2.5 hours and the resulting methyl 5(4-chloro-3-methylphenoxy)-2-nitrobenzoate isolated in the usual way; the ester had a melting point of 85°-87° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04780128 |
| Source dataset | uspto-grants-1988_10 |
| ORD ID | ord-540760b9910f40eeb38fc151a8ea8215 |
| Source note | uspto-grants-1988_10 |