Phenol → HCID 21287074, compound

HRID 868463Notes

Reaction equation

HRID 868463 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]([N+:12]([O-:14])=[O:13])=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[Na].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][C:18]=1[CH3:24].[H-].[Na+].C1(O)C=CC=CC=1>CN(C)C=O>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([O:23][C:2]2[CH:3]=[CH:4][C:5]([N+:12]([O-:14])=[O:13])=[C:6]([CH:11]=2)[C:7]([O:9][CH3:10])=[O:8])=[CH:19][C:18]=1[CH3:24]

Participants

7

Reactant 5

HCID 996PhenolHCID 17324-Chloro-3-methylphenolHCID 24758Sodium hydrideHCID 51520495-Fluoro-2-nitrobenzoic acid methyl esterHCID 5360545Sodium

Product 1

HCID 21287074HCID 21287074, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Methyl 5-fluoro-2-nitrobenzoate was reacted with the sodium salt of 4-chloro-3-methylphenol (prepared from sodium hydride and the phenol) in dimethylformamide at 100° C. for 2.5 hours and the resulting methyl 5(4-chloro-3-methylphenoxy)-2-nitrobenzoate isolated in the usual way; the ester had a melting point of 85°-87° C.

Sources & evidence

ORD record
ord-540760b9910f40eeb38fc151a8ea8215
Source dataset
uspto-grants-1988_10
Patent number
US04780128

Reaction notes

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