Cyclopentane-1,1-diacetic anhydride → 8-Hydroxy-8-azaspiro[4.5]decane-7,9-dione

HRID 868547Notes

Reaction equation

HRID 868547 reaction equation
[CH2:1]1[C:5]2([CH2:10][C:9](=[O:11])[O:8][C:7](=O)[CH2:6]2)[CH2:4][CH2:3][CH2:2]1.Cl.[NH2:14][OH:15]>N1C=CC=CC=1>[OH:15][N:14]1[C:9](=[O:11])[CH2:10][C:5]2([CH2:4][CH2:3][CH2:2][CH2:1]2)[CH2:6][C:7]1=[O:8]

Participants

4

Reactant 2

HCID 79743Cyclopentane-1,1-diacetic anhydrideHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 142805828-Hydroxy-8-azaspiro[4.5]decane-7,9-dione

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 8-oxaspiro[4.5]decan-7,9-dione (5.0 g) and hydroxylamine hydrochloride (2.1 g) in 75 ml of anhydrous pyridine was heated to 80° C. with stirring under N2.

Sources & evidence

ORD record
ord-666792a9a0174e1c977846150b5db81e
Source dataset
uspto-grants-1988_10
Patent number
US04780466

Reaction notes

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