Diisopropylethylamine → 8-{3-[4-(3-Methylsulfanyl-phenyl)-piperazin-1-yl]-propoxy}-8-aza-spiro[4.5]decane-7,9-dione

HRID 868550Notes

Reaction equation

HRID 868550 reaction equation
Br[CH2:2][CH2:3][CH2:4][O:5][N:6]1[C:15](=[O:16])[CH2:14][C:9]2([CH2:13][CH2:12][CH2:11][CH2:10]2)[CH2:8][C:7]1=[O:17].[CH3:18][S:19][C:20]1[CH:21]=[C:22]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[CH:23]=[CH:24][CH:25]=1.C(N(C(C)C)CC)(C)C>CC#N>[CH3:18][S:19][C:20]1[CH:21]=[C:22]([N:26]2[CH2:31][CH2:30][N:29]([CH2:2][CH2:3][CH2:4][O:5][N:6]3[C:15](=[O:16])[CH2:14][C:9]4([CH2:13][CH2:12][CH2:11][CH2:10]4)[CH2:8][C:7]3=[O:17])[CH2:28][CH2:27]2)[CH:23]=[CH:24][CH:25]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 129231801-(3-(Methylthio)phenyl)piperazineHCID 142805838-(3-Bromopropyloxy)-8-azaspiro[4.5]decan-7,9-dione

Product 1

HCID 142806078-{3-[4-(3-Methylsulfanyl-phenyl)-piperazin-1-yl]-propoxy}-8-aza-spiro[4.5]decane-7,9-dione

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 8-(3-bromopropyloxy)-8-azaspiro[4.5]decan-7,9-dione (4.0 g), 1-(3-methylthiophenyl)piperazine (2.75 g) and diisopropylethylamine (4.6 ml) was stirred in 100 ml of dry CH3CN at room temperature under N2.

Sources & evidence

ORD record
ord-09ebaccc54994651bbf8ac30fed69ca7
Source dataset
uspto-grants-1988_10
Patent number
US04780466

Reaction notes

Loading…