HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 8-[3-[4-(2-Pyrimidinyl)-1-piperazinyl]propyloxy]-8-azaspiro-[4.5]decan-7,9-dione hydrochloride hemihydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Piperazinylpyrimidine dihydrochloride | HCID 11680272 | — |
| Reactant | 8-(3-Bromopropyloxy)-8-azaspiro[4.5]decan-7,9-dione | HCID 14280583 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 8-[3-[4-(2-Pyrimidinyl)-1-piperazinyl]propyloxy]-8-azaspiro-[4.5]decan-7,9-dione hydrochloride hemihydrate | HCID 131715733 | — |
Reaction Steps
To a mixture of 8-(3-bromopropyloxy)-8-azaspiro[4.5]decan-7,9-dione (4.0 g) and 1-(2-pyrimidinyl)piperazine dihydrochloride (3.13 g) in 100 ml of dry CH3CN were added K2CO3 (52.9 mmol) and NaI (200 mg). The mixture was heated to 80° with stirring under N2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04780466 |
| Source dataset | uspto-grants-1988_10 |
| ORD ID | ord-ae8aeebdd77643778ad1bce741e6ff75 |
| Source note | uspto-grants-1988_10 |