HRID868551

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5238

Sodium Iodide

INa

HCID11430

Potassium Carbonate

CK2O3

HCID11680272

2-Piperazinylpyrimidine dihydrochloride

C8H14Cl2N4

HCID14280583

未命名化合物

PRODUCTS

生成物

结构：Cl.Cl.O.O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(c2ncccn2)CC1.O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(c2ncccn2)CC1

HCID131715733

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

To a mixture of 8-(3-bromopropyloxy)-8-azaspiro[4.5]decan-7,9-dione (4.0 g) and 1-(2-pyrimidinyl)piperazine dihydrochloride (3.13 g) in 100 ml of dry CH3CN were added K2CO3 (52.9 mmol) and NaI (200 mg). The mixture was heated to 80° with stirring under N2.

WORKUP

后处理

temperatureThe mixture was heated to 80°

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ae8aeebdd77643778ad1bce741e6ff75
来源数据集: uspto-grants-1988_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04780466
来源说明: uspto-grants-1988_10

反应 SMILES

Br[CH2:2][CH2:3][CH2:4][O:5][N:6]1[C:15](=[O:16])[CH2:14][C:9]2([CH2:13][CH2:12][CH2:11][CH2:10]2)[CH2:8][C:7]1=[O:17].[ClH:18].Cl.[N:20]1[CH:25]=[CH:24][CH:23]=[N:22][C:21]=1[N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1.C([O-])([O-])=O.[K+].[K+].[Na+].[I-]>CC#N>[OH2:5].[ClH:18].[N:20]1[CH:25]=[CH:24][CH:23]=[N:22][C:21]=1[N:26]1[CH2:31][CH2:30][N:29]([CH2:2][CH2:3][CH2:4][O:5][N:6]2[C:15](=[O:16])[CH2:14][C:9]3([CH2:13][CH2:12][CH2:11][CH2:10]3)[CH2:8][C:7]2=[O:17])[CH2:28][CH2:27]1.[N:20]1[CH:25]=[CH:24][CH:23]=[N:22][C:21]=1[N:26]1[CH2:31][CH2:30][N:29]([CH2:2][CH2:3][CH2:4][O:5][N:6]2[C:15](=[O:16])[CH2:14][C:9]3([CH2:13][CH2:12][CH2:11][CH2:10]3)[CH2:8][C:7]2=[O:17])[CH2:28][CH2:27]1.[ClH:18]