Diisopropylethylamine → 8-[3-(4-Benzothiazol-2-yl-piperazin-1-yl)-propoxy]-8-aza-spiro[4.5]decane-7,9-dione

HRID 868552Notes

Reaction equation

HRID 868552 reaction equation
Br[CH2:2][CH2:3][CH2:4][O:5][N:6]1[C:15](=[O:16])[CH2:14][C:9]2([CH2:13][CH2:12][CH2:11][CH2:10]2)[CH2:8][C:7]1=[O:17].[S:18]1[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[N:20]=[C:19]1[N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1.C(N(C(C)C)CC)(C)C>CC#N>[S:18]1[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[N:20]=[C:19]1[N:27]1[CH2:28][CH2:29][N:30]([CH2:2][CH2:3][CH2:4][O:5][N:6]2[C:15](=[O:16])[CH2:14][C:9]3([CH2:13][CH2:12][CH2:11][CH2:10]3)[CH2:8][C:7]2=[O:17])[CH2:31][CH2:32]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 5921222-Piperazin-1-yl-1,3-benzothiazoleHCID 142805838-(3-Bromopropyloxy)-8-azaspiro[4.5]decan-7,9-dione

Product 1

HCID 142805938-[3-(4-Benzothiazol-2-yl-piperazin-1-yl)-propoxy]-8-aza-spiro[4.5]decane-7,9-dione

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 8-(3-bromopropyloxy)-8-azaspiro[4.5]decan-7,9-dione (5.0 g) and 1-(2-benzothiazolyl)piperazine (3.6 g) in 100 ml of anhydrous CH3CN was added diisopropylethylamine (5.7 ml). The mixture was stirred at room temperature for 18 hours.

Sources & evidence

ORD record
ord-3a1130211e3441f1b4d4fe31e9c8065c
Source dataset
uspto-grants-1988_10
Patent number
US04780466

Reaction notes

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