Methanol → HCID 14280606, compound

HRID 868555Notes

Reaction equation

HRID 868555 reaction equation
CO[C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][O:18][N:19]3[C:28](=[O:29])[CH2:27][C:22]4([CH2:26][CH2:25][CH2:24][CH2:23]4)[CH2:21][C:20]3=[O:30])[CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[CH3:31][OH:32].[BH4-].[Na+]>C(Cl)Cl>[CH3:31][O:32][C:4]1[CH:3]=[CH:8][CH:7]=[CH:6][C:5]=1[N:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][CH2:17][O:18][N:19]2[C:20](=[O:30])[CH2:21][C:22]3([CH2:26][CH2:25][CH2:24][CH2:23]3)[CH2:27][CH:28]2[OH:29])[CH2:13][CH2:14]1

Participants

5

Reactant 3

HCID 887MethanolHCID 4311764Sodium borohydrideHCID 14280590HCID 14280590, compound

Product 1

HCID 14280606HCID 14280606, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution prepared from 8-[3-[4-(3-methoxyphenyl)-1-piperazinyl]propyloxy]-8-azaspiro[4.5]decan-7,9-dione (5.0 g), 300 ml of CH3OH and 100 CH2Cl2 was added NaBH4 (1.8 g) with stirring. The mixture was stirred at room temperature.

Workup

  1. stirringThe mixture was stirred at room temperature

Sources & evidence

ORD record
ord-6f6ad9e677c8492ebc95cef928355d61
Source dataset
uspto-grants-1988_10
Patent number
US04780466

Reaction notes

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