5-Bromoisatin → 5-Bromo-1-(2-diisopropylaminoethyl)isatin

HRID 868563Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[O:12].Cl.[CH:14]([N:17]([CH:21]([CH3:23])[CH3:22])[CH2:18][CH2:19]Cl)([CH3:16])[CH3:15]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:19][CH2:18][N:17]([CH:21]([CH3:23])[CH3:22])[CH:14]([CH3:16])[CH3:15])[C:6](=[O:11])[C:5]2=[O:12]

Participants

Reactant 2

HCID 68895-Bromoisatin

HCID 779422-Chloroethyldiisopropylammonium chloride

Product 1

HCID 139344155-Bromo-1-(2-diisopropylaminoethyl)isatinYield 82.9%

Procedure

By using 5-bromoisatin and 2-diisopropylaminoethyl chloride hydrochloride, a method analogous to that described in Reference Example 7 was carried out to obtain 5-bromo-1-(2-diisopropylaminoethyl)isatin having a melting point of 91°-93° C. (yield: 82.9%).

Sources & evidence

ORD record: ord-2064c85ec7fc417fb4cd615a476618f6
Source dataset: uspto-grants-1988_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04780477

Reaction notes

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