Triethylamine → HCID 14278831, compound

HRID 868571Notes

Reaction equation

HRID 868571 reaction equation
[CH:1]([NH:4][CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)([CH3:3])[CH3:2].C(N(CC)CC)C.[C:18]([O:21][CH2:22][C:23](Cl)=[O:24])(=[O:20])[CH3:19]>ClCCl>[C:18]([O:21][CH2:22][C:23]([N:4]([CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)[CH:1]([CH3:3])[CH3:2])=[O:24])(=[O:20])[CH3:19]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 26297Acetoxyacetyl chlorideHCID 62386Cyclohexylisopropylamine

Product 1

HCID 14278831HCID 14278831, compoundYield 99.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 5.0 g of N-isopropylcyclohexylamine and 4.3 g of triethylamine in 100 ml of dry dichloromethane was added dropwise 5.8 g of acetoxyacetyl chloride with stirring under ice-cooling, and the mixture was stirred for 16 hours at room temperature. The reaction mixture was successively washed with an aqueous sodium bicarbonate solution and water, dried under reduced pressure to obtain 8.5 g of 2-acetoxy-N-cyclohexyl-N-isopropylacetamide in an oil.

Workup

  1. temperaturecooling
  2. stirringthe mixture was stirred for 16 hours at room temperature
  3. washThe reaction mixture was successively washed with an aqueous sodium bicarbonate solution and water
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-bd5eb83d86f64b4dbdd9a116d49803c4
Source dataset
uspto-grants-1988_10
Patent number
US04780477

Reaction notes

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