Thionyl Chloride → HCID 12841523, compound

HRID 868572Notes

Reaction equation

HRID 868572 reaction equation
[CH:1]([N:4]([CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)[CH2:5][CH2:6]O)([CH3:3])[CH3:2].S(Cl)([Cl:16])=O>C1C=CC=CC=1>[ClH:16].[CH:1]([N:4]([CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)[CH2:5][CH2:6][Cl:16])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 12841520HCID 12841520, compound

Product 1

HCID 12841523HCID 12841523, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

6.0 Grams of the above alcohol compound obtained was dissolved in 100 ml of dry benzene, and to this solution was added dropwise 3.2 ml of thionyl chloride with stirring at room temperature. The mixture was heated under refulx for 4 hours. The reaction mixture was concentrated under reduced pressure, and the residue was triturated with diethyl ether. The precipitated crystals were collected by filtration to obtain 7.4 g of 2-(N-isopropylcyclohexylamino)ethyl chloride hydrochloride having a melting point of 99°-103° C.

Workup

  1. temperatureThe mixture was heated under refulx for 4 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customthe residue was triturated with diethyl ether
  4. filtrationThe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-fbb1a632bb604df48d08a7458a5670fc
Source dataset
uspto-grants-1988_10
Patent number
US04780477

Reaction notes

Loading…