Isatin → HCID 13934425, compound

HRID 868573Notes

Reaction equation

HRID 868573 reaction equation
Cl.[CH:2]([N:5]([CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)[CH2:6][CH2:7]Cl)([CH3:4])[CH3:3].[NH:15]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:18](=[O:19])[C:16]1=[O:17]>>[CH:2]([N:5]([CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)[CH2:6][CH2:7][N:15]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:18](=[O:19])[C:16]1=[O:17])([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 7054IsatinHCID 12841523HCID 12841523, compound

Product 1

HCID 13934425HCID 13934425, compoundYield 75.5%

Procedure

By using the 2-(N-isopropylcyclohexylamino)ethyl chloride hydrochloride obtained and isatin, a method analogous to that described in Reference Example 1 was carried out to obtain 1-[2-(N-isopropylcyclohexylamino)ethyl]isatin having a melting point of 103°-106° C (yield: 75.5%, recrystallizing solvent: ethyl acetatehexane).

Workup

  1. customobtained

Sources & evidence

ORD record
ord-3ca732b039044c698cb5cc0e5f4a0f8b
Source dataset
uspto-grants-1988_10
Patent number
US04780477

Reaction notes

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