Hydrochloric Acid → [(E)-[1-[2-[di(propan-2-yl)amino]ethyl]-2-oxoindol-3-ylidene]amino]urea;hydrochloride

Participants

Reaction Steps

To a suspension of 4.97 g of (E)-1-(2-diisopropylaminoethyl)isatin 3-semicarbazone in 370 ml of methanol was added 15.0 ml of a 1N-hydrochloric acid to make a solution. The solution was concentrated under reduced pressure, and diethyl ether was added to the residue. The precipitates were collected by filtration and recrystallized from ethanol to obtain 5.37 g of (E)-1-(2-diisopropylaminoethyl)isatin 3-semicarbazone hydrochloride having a melting point of 255°-25° C. (decomposition).

Provenance & Evidence