反应详情

To a suspension of 4.97 g of (E)-1-(2-diisopropylaminoethyl)isatin 3-semicarbazone in 370 ml of methanol was added 15.0 ml of a 1N-hydrochloric acid to make a solution. The solution was concentrated under reduced pressure, and diethyl ether was added to the residue. The precipitates were collected by filtration and recrystallized from ethanol to obtain 5.37 g of (E)-1-(2-diisopropylaminoethyl)isatin 3-semicarbazone hydrochloride having a melting point of 255°-25° C. (decomposition).

1. concentrationThe solution was concentrated under reduced pressure, and diethyl ether
2. additionwas added to the residue
3. filtrationThe precipitates were collected by filtration
4. customrecrystallized from ethanol