Hydrochloric Acid → [(E)-[1-[2-[di(propan-2-yl)amino]ethyl]-2-oxoindol-3-ylidene]amino]urea;hydrochloride

HRID 868585Notes

Reaction equation

HRID 868585 reaction equation
[CH:1]([N:4]([CH:22]([CH3:24])[CH3:23])[CH2:5][CH2:6][N:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)/[C:10](=[N:17]\[NH:18][C:19]([NH2:21])=[O:20])/[C:8]1=[O:9])([CH3:3])[CH3:2].[ClH:25]>CO>[ClH:25].[CH:22]([N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][CH2:6][N:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)/[C:10](=[N:17]\[NH:18][C:19]([NH2:21])=[O:20])/[C:8]1=[O:9])([CH3:24])[CH3:23]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178457379HCID 178457379, compound

Product 1

HCID 178457382[(E)-[1-[2-[di(propan-2-yl)amino]ethyl]-2-oxoindol-3-ylidene]amino]urea;hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 4.97 g of (E)-1-(2-diisopropylaminoethyl)isatin 3-semicarbazone in 370 ml of methanol was added 15.0 ml of a 1N-hydrochloric acid to make a solution. The solution was concentrated under reduced pressure, and diethyl ether was added to the residue. The precipitates were collected by filtration and recrystallized from ethanol to obtain 5.37 g of (E)-1-(2-diisopropylaminoethyl)isatin 3-semicarbazone hydrochloride having a melting point of 255°-25° C. (decomposition).

Workup

  1. concentrationThe solution was concentrated under reduced pressure, and diethyl ether
  2. additionwas added to the residue
  3. filtrationThe precipitates were collected by filtration
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-7a2924e74f664c44a9680d2c3c4ef64b
Source dataset
uspto-grants-1988_10
Patent number
US04780477

Reaction notes

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