Semicarbazide hydrochloride → HCID 178457387, compound

HRID 868594Notes

Reaction equation

[CH:1]([N:4]([CH:19]([CH3:21])[CH3:20])[CH2:5][CH2:6][N:7]1[C:17]2[C:12](=[CH:13][C:14]([F:18])=[CH:15][CH:16]=2)[C:10](=O)[C:8]1=[O:9])([CH3:3])[CH3:2].Cl.[NH2:23][NH:24][C:25]([NH2:27])=[O:26]>>[CH:1]([N:4]([CH:19]([CH3:21])[CH3:20])[CH2:5][CH2:6][N:7]1[C:17]2[C:12](=[CH:13][C:14]([F:18])=[CH:15][CH:16]=2)/[C:10](=[N:23]\[NH:24][C:25]([NH2:27])=[O:26])/[C:8]1=[O:9])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 11236Semicarbazide hydrochloride

HCID 13934411HCID 13934411, compound

Product 1

HCID 178457387HCID 178457387, compoundYield 86.5%

Procedure

By using 1-(2-diisopropylaminoethyl)-5-fluoroisatin and semicarbazide hydrochloride, a method analogous to that described in Example 6 was carried out to obtain (E)-1-(2-diisopropylaminoethyl)-5-fluoroisatin 3-semicarbazone having a melting point of 158°-160° C. (yield: 86.5%, recrystallizing solvent: chloroform-hexane).

Sources & evidence

ORD record: ord-1788772ef4384d5d9a4c0bf3445396f0
Source dataset: uspto-grants-1988_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04780477

Reaction notes

Loading…