Semicarbazide hydrochloride → HCID 178457385, compound

HRID 868595Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][CH2:12][N:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:16])[CH3:15])[C:6](=[O:20])[C:5]2=O.Cl.[NH2:23][NH:24][C:25]([NH2:27])=[O:26]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][CH2:12][N:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:16])[CH3:15])[C:6](=[O:20])/[C:5]/2=[N:23]/[NH:24][C:25]([NH2:27])=[O:26]

Participants

Reactant 2

HCID 11236Semicarbazide hydrochloride

HCID 13934412HCID 13934412, compound

Product 1

HCID 178457385HCID 178457385, compoundYield 49.4%

Procedure

By using 5-chloro-1-(2-diisopropylaminoethyl)isatin and semicarbazide hydrochloride, a method analogous to that described in Example 4 was carried out to obtain (E)-5-chloro-1-(2-diisopropylaminoethyl)isatin 3-semicarbazone having a melting point of 154°-155° C. (yield: 49.4%, recrystallizing solvent: chloroform-hexane).

Sources & evidence

ORD record: ord-549189e8914649f188239124b89a3030
Source dataset: uspto-grants-1988_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04780477

Reaction notes

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