Semicarbazide hydrochloride → [(E)-[1-[3-[di(propan-2-yl)amino]propyl]-5-methyl-2-oxoindol-3-ylidene]amino]urea

HRID 868604Notes

Reaction equation

[CH:1]([N:4]([CH:20]([CH3:22])[CH3:21])[CH2:5][CH2:6][CH2:7][N:8]1[C:18]2[C:13](=[CH:14][C:15]([CH3:19])=[CH:16][CH:17]=2)[C:11](=O)[C:9]1=[O:10])([CH3:3])[CH3:2].Cl.[NH2:24][NH:25][C:26]([NH2:28])=[O:27]>>[CH:1]([N:4]([CH:20]([CH3:22])[CH3:21])[CH2:5][CH2:6][CH2:7][N:8]1[C:18]2[C:13](=[CH:14][C:15]([CH3:19])=[CH:16][CH:17]=2)/[C:11](=[N:24]\[NH:25][C:26]([NH2:28])=[O:27])/[C:9]1=[O:10])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 11236Semicarbazide hydrochloride

HCID 139344231-(3-Diisopropylaminopropyl)-5-methylisatin

Product 1

HCID 178422539[(E)-[1-[3-[di(propan-2-yl)amino]propyl]-5-methyl-2-oxoindol-3-ylidene]amino]ureaYield 72.2%

Procedure

By using 1-(3-diisopropylaminopropyl)-5-methylisatin and semicarbazide hydrochloride, a method analogous to that described in Example 4 was carried out to obtain (E)-1-(3-diisopropylaminopropyl)-5-methylisatin 3-semicarbazone having a melting point of 145°-148° C. (yield: 72.2%).

Sources & evidence

ORD record: ord-9bcdc69cddfc49f480b9b80b300c4af4
Source dataset: uspto-grants-1988_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04780477

Reaction notes

Loading…