Semicarbazide hydrochloride → HCID 178457377, compound

HRID 868607Notes

Reaction equation

[CH:1]([N:4]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:5][CH2:6][N:7]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:10](=O)[C:8]1=[O:9])([CH3:3])[CH3:2].Cl.[NH2:26][NH:27][C:28]([NH2:30])=[O:29]>>[CH:1]([N:4]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:5][CH2:6][N:7]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)/[C:10](=[N:26]\[NH:27][C:28]([NH2:30])=[O:29])/[C:8]1=[O:9])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 11236Semicarbazide hydrochloride

HCID 543673991-[2-(N-isopropylbenzylamino)ethyl]isatin

Product 1

HCID 178457377HCID 178457377, compoundYield 52.7%

Procedure

By using 1-[2-(N-isopropylbenzylamino)ethyl]isatin and semicarbazide hydrochloride, a method analogous to that described in Example 6 was carried out to obtain (E)-1-[2-(N-isopropylbenzylamino)ethyl]isatin 3-semicarbazone having a melting point of 193°-194° C. (yield: 52.7%, recrystallizing solvent: ethanol).

Sources & evidence

ORD record: ord-2604685e364a4854811e5a276a6ebe1b
Source dataset: uspto-grants-1988_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04780477

Reaction notes

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