Water → HCID 21268593, compound

HRID 868625Notes

Reaction equation

HRID 868625 reaction equation
C[O:2][C:3]1[C:11]([CH2:12][C:13]([OH:15])=[O:14])=[CH:10][C:6]2[CH:7]=[CH:8][O:9][C:5]=2[C:4]=1[C:16](=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.O>C(O)(=O)C.Br>[OH:2][C:3]1[C:11]([CH2:12][C:13]([OH:15])=[O:14])=[CH:10][C:6]2[CH:7]=[CH:8][O:9][C:5]=2[C:4]=1[C:16](=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

5

Reactant 2

HCID 962WaterHCID 21268645HCID 21268645, compound

Product 1

HCID 21268593HCID 21268593, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 260Hydrogen BromideSolvent

Procedure

6-Methoxy-7-benzoylbenzofuran-5-ylacetic acid (5.0 g) was heated at reflux in a mixture of acetic acid (50 ml) and 48% hydrobromic acid (50 ml). After the reaction was completed, approximately 1 hour, the cooled solution was added to 400 ml of water which was then extracted with ethyl acetate. The combined organic extracts were washed four times with water, dried with sodium sulfate and evaporated to give 6-hydroxy-7-benzoylbenzofuran-5-ylacetic acid.

Workup

  1. extractionwas then extracted with ethyl acetate
  2. washThe combined organic extracts were washed four times with water
  3. dry with materialdried with sodium sulfate
  4. customevaporated

Sources & evidence

ORD record
ord-18352820d948460ca64a2dbd849326e8
Source dataset
uspto-grants-1988_10
Patent number
US04780480

Reaction notes

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