Allyl Alcohol → HCID 21268550, compound

HRID 868628Notes

Reaction equation

HRID 868628 reaction equation
[CH2:1]([OH:4])[CH:2]=[CH2:3].[CH3:5][C:6]1[CH:26]=[CH:25][C:9]([C:10]([C:12]2[C:20]3[O:19][CH2:18][CH2:17][C:16]=3[CH:15]=[C:14]([CH2:21][C:22](Cl)=[O:23])[CH:13]=2)=[S:11])=[CH:8][CH:7]=1>C(#N)C.C(N(CC)CC)C>[CH3:5][C:6]1[CH:26]=[CH:25][C:9]([C:10]([C:12]2[C:20]3[O:19][CH:18]=[CH:17][C:16]=3[CH:15]=[C:14]([CH2:21][C:22]([O:4][CH2:1][CH:2]=[CH2:3])=[O:23])[CH:13]=2)=[S:11])=[CH:8][CH:7]=1

Participants

5

Reactant 2

HCID 7858Allyl AlcoholHCID 21268803HCID 21268803, compound

Product 1

HCID 21268550HCID 21268550, compound

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 8471TriethylamineSolvent

Procedure

Allyl alcohol (2.0 ml) was added to a solution of 7-(4-methylthiobenzoyl)-2,3-dihydrobenzofuran-5-ylacetyl chloride (2.0 g) in acetonitrile (100 ml) and triethylamine (2.0 ml). This solution was stirred at room temperature for 12 hours. The solvent was then evaporated to dryness and the residue was taken up in a solution of ethyl acetate/water, washed 3 times with water, the ethyl acetate dried and evaporated to dryness after which the residue was purified by chromatography.

Workup

  1. customThe solvent was then evaporated to dryness
  2. washwashed 3 times with water
  3. dry with materialthe ethyl acetate dried
  4. customevaporated to dryness after which the residue
  5. customwas purified by chromatography

Sources & evidence

ORD record
ord-2053fc01c7654201b4eddc9408796667
Source dataset
uspto-grants-1988_10
Patent number
US04780480

Reaction notes

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