Calcium Carbonate → HCID 70353199, compound

HRID 868630Notes

Reaction equation

HRID 868630 reaction equation
[C:1]([C:9]1[C:17]2[O:16][CH:15]=[CH:14][C:13]=2[CH:12]=[C:11]([CH2:18][C:19]([OH:21])=[O:20])[CH:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+].[C:24]([C:32]1[C:40]2[O:39][CH:38]=[CH:37][C:36]=2[CH:35]=[C:34]([CH2:41][C:42]([O-:44])=[O:43])[CH:33]=1)(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.[K+].C(=O)([O-])[O-].[Ca+2:50].[Cl-].[NH4+].[Ca]>CO.Cl.O>[C:1]([C:9]1[C:17]2[O:16][CH:15]=[CH:14][C:13]=2[CH:12]=[C:11]([CH2:18][C:19]([O-:21])=[O:20])[CH:10]=1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[Ca+2:50].[C:24]([C:32]1[C:40]2[O:39][CH:38]=[CH:37][C:36]=2[CH:35]=[C:34]([CH2:41][C:42]([O-:44])=[O:43])[CH:33]=1)(=[O:31])[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

10

Reactant 6

HCID 10112Calcium Carbonate2×HCID 14797Potassium HydroxideHCID 25517Ammonium ChlorideHCID 5460341CalciumHCID 137043977-Benzoyl-5-benzofuranacetic acidHCID 23699967HCID 23699967, compound2×

Product 1

HCID 70353199HCID 70353199, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a solution of 200 mg of 7-benzoylbenzofuran-5-ylacetic acid in 5 ml of methanol is added a 1 molar equivalent of potassium hydroxide in the form of a 0.1N solution, thus, yielding a solution containing potassium 7-benzoylbenzofuran-5-ylacetate. A solution of 60 mg of calcium carbonate dissolved in the minimum amount of 1N hydrochloric acid necessary to effect solution of the calcium carbonate is buffered with 150 mg of solid ammonium chloride followed by the addition of 5 ml of water. The thus obtained buffered calcium solution is then added to the solution of potassium 7-benzoylbenzofuran-5-ylacetate and the precipitate which forms is collected by filtration, washed with water and air dried to yield calcium 7-benzoylbenzofuran-5-ylacetate.

Workup

  1. customthus, yielding a solution
  2. customThe thus obtained
  3. filtrationthe precipitate which forms is collected by filtration
  4. washwashed with water and air
  5. customdried

Sources & evidence

ORD record
ord-dba6f3010fb043a098a32a851544e2f2
Source dataset
uspto-grants-1988_10
Patent number
US04780480

Reaction notes

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