Hydrogen Peroxide → HCID 178474455, compound

HRID 868635Notes

Reaction equation

HRID 868635 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([NH2:9])[N:3]=1.[OH:10]O.[C:12](OC(=O)C)(=[O:14])[CH3:13]>C(O)C>[C:12]([NH:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([NH2:9])[N+:3]=1[O-:10])(=[O:14])[CH3:13]

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 7918Acetic AnhydrideHCID 674322,4-Diamino-6-chloropyrimidine

Product 1

HCID 178474455HCID 178474455, compoundYield 38%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
40 °C

Procedure

5.0 g (0.035 mole) of 2,6-diamino-4-chloropyrimidine are dissolved in 70 ml of anhydrous ethyl alcohol. 7 ml of a 70% aqueous hydrogen peroxide solution and 14 ml of acetic anhydride are dropped into it while stirring at a temperature of 40° C. in half an hour. The mixture is stirred at 60° C. for further two hours, then it is cooled and the flaky crystals are filtered out, washed with ethanol and dried. Thus 2.67 g (38%) of 2-acetamido-4-chloro-6-aminopyrimidine-1-oxide are obtained.

Workup

  1. stirringThe mixture is stirred at 60° C. for further two hours
  2. temperatureit is cooled
  3. filtrationthe flaky crystals are filtered out
  4. washwashed with ethanol
  5. customdried

Sources & evidence

ORD record
ord-a6469beae619478c889d8bd80f4abe11
Source dataset
uspto-grants-1988_10
Patent number
US04780537

Reaction notes

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