1,4-Dioxane hydrochloride → HCID 68116305, compound

HRID 868642Notes

Reaction equation

HRID 868642 reaction equation
[ClH:1].O1CCOCC1.[CH3:8][O:9][C:10](=[O:40])[C@H:11]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[NH:12][C:13](=[O:32])[C@H:14]([CH2:28][C:29](=[O:31])[OH:30])[NH:15][C:16](=[O:27])[C@@H:17]([CH3:26])[NH:18]C(OC(C)(C)C)=O>C(OCC)C>[ClH:1].[CH3:8][O:9][C:10](=[O:40])[C@H:11]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[NH:12][C:13](=[O:32])[C@H:14]([CH2:28][C:29](=[O:30])[OH:31])[NH:15][C:16](=[O:27])[C@@H:17]([CH3:26])[NH2:18]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 54198751HCID 54198751, compound

Product 1

HCID 68116305HCID 68116305, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To 20 ml of 4N-HCl/dioxane was added 2.0 g of N-t-butoxycarbonyl-D-alanyl-α-L-aspartyl-L-phenylalanine methyl ester under ice cooling. The mixture was stirred for 1 hour. To the reaction mixture was added 150 ml of ethyl ether. Precipitated crystals were collected by filtration. Yield, 1.6 g; m.p., 205°-208° C. (decomposed).

Workup

  1. customPrecipitated crystals
  2. filtrationwere collected by filtration
  3. customYield

Sources & evidence

ORD record
ord-87574ee0dff742e88212d80a97f7dc30
Source dataset
uspto-grants-1988_10
Patent number
US04780528

Reaction notes

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