1,4-Dioxane hydrochloride → HCID 68116305, compound

Participants

Reaction Steps

To 20 ml of 4N-HCl/dioxane was added 2.0 g of N-t-butoxycarbonyl-D-alanyl-α-L-aspartyl-L-phenylalanine methyl ester under ice cooling. The mixture was stirred for 1 hour. To the reaction mixture was added 150 ml of ethyl ether. Precipitated crystals were collected by filtration. Yield, 1.6 g; m.p., 205°-208° C. (decomposed).

Provenance & Evidence