Sodium Bicarbonate → HCID 14151456, compound

Participants

Reaction Steps

In 50ml of water was dissolved 1.1 g of D-seryl-α-L-aspartyl-L-phenylalanine methyl ester hydrochloride. After the solution was neutralized with sodium bicarbonate, the solution was adsorbed on a column (50 ml) of styrene divinyl type adsorption resin (manufactured by Mitsubishi Chemical Industries, Ltd. "Adsorption Resin SP-207"). After washing with 200 ml of water, elution was performed with 200 ml of water/methanol=50/50 vol%. The solvent was removed by distillation to obtain 0.8 g of white powders. m.p. 196°-199° C.

Provenance & Evidence