Sodium Bicarbonate → HCID 14151456, compound

HRID 868644Notes

Reaction equation

HRID 868644 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:28])[C@H:5]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[NH:6][C:7](=[O:20])[C@H:8]([CH2:16][C:17](=[O:19])[OH:18])[NH:9][C:10](=[O:15])[C@@H:11]([CH2:13][OH:14])[NH2:12].C(=O)(O)[O-].[Na+]>O>[CH3:2][O:3][C:4](=[O:28])[C@H:5]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[NH:6][C:7](=[O:20])[C@H:8]([CH2:16][C:17](=[O:18])[OH:19])[NH:9][C:10](=[O:15])[C@@H:11]([CH2:13][OH:14])[NH2:12]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 68116332HCID 68116332, compound

Product 1

HCID 14151456HCID 14151456, compoundYield 79.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In 50ml of water was dissolved 1.1 g of D-seryl-α-L-aspartyl-L-phenylalanine methyl ester hydrochloride. After the solution was neutralized with sodium bicarbonate, the solution was adsorbed on a column (50 ml) of styrene divinyl type adsorption resin (manufactured by Mitsubishi Chemical Industries, Ltd. "Adsorption Resin SP-207"). After washing with 200 ml of water, elution was performed with 200 ml of water/methanol=50/50 vol%. The solvent was removed by distillation to obtain 0.8 g of white powders. m.p. 196°-199° C.

Workup

  1. washAfter washing with 200 ml of water, elution
  2. customThe solvent was removed by distillation

Sources & evidence

ORD record
ord-cbb760223e9b4f329a33c71dd4a60b9d
Source dataset
uspto-grants-1988_10
Patent number
US04780528

Reaction notes

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