alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride → alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester

HRID 868655Notes

Reaction equation

HRID 868655 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:28])[C@H:5]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[NH:6][C:7](=[O:20])[C@:8]([NH2:19])([CH2:15][C:16](=[O:18])[OH:17])[NH:9][C:10](=[O:14])[CH:11]([CH3:13])[CH3:12]>O>[CH3:2][O:3][C:4](=[O:28])[C@H:5]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[NH:6][C:7](=[O:20])[C@:8]([NH2:19])([CH2:15][C:16](=[O:17])[OH:18])[NH:9][C:10](=[O:14])[CH:11]([CH3:13])[CH3:12]

Participants

3

Reactant 1

HCID 86742496alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride

Product 1

HCID 86742497alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl esterYield 85.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 1.8 g α-aminoisobutyryl-α-L-aspartyl-L-phenylalanine methyl ester hydrochloride in 50 ml water was allowed to pass through a column (50 ml) packed with a weakly basic anion-exchange resin (Dow Chemical Co., "IRA-68"), and the resin was washed with 100 ml water. The washings were added to the effluent, and the combined solution was concentrated under reduced pressure, giving 1.4 g of white powder. M.p.: 168°-170° C.

Workup

  1. washthe resin was washed with 100 ml water
  2. additionThe washings were added to the effluent, and the combined solution
  3. concentrationwas concentrated under reduced pressure

Sources & evidence

ORD record
ord-e239165540134d59bfa22ec56a6f3d39
Source dataset
uspto-grants-1988_10
Patent number
US04780528

Reaction notes

Loading…