alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride → alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester

Participants

Reaction Steps

A solution of 1.8 g α-aminoisobutyryl-α-L-aspartyl-L-phenylalanine methyl ester hydrochloride in 50 ml water was allowed to pass through a column (50 ml) packed with a weakly basic anion-exchange resin (Dow Chemical Co., "IRA-68"), and the resin was washed with 100 ml water. The washings were added to the effluent, and the combined solution was concentrated under reduced pressure, giving 1.4 g of white powder. M.p.: 168°-170° C.

Provenance & Evidence