HCID 86729187, compound → HCID 71295260, compound

HRID 868816Notes

Reaction equation

HRID 868816 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:9]=[N:10][N:11](C(OC(C)(C)C)=O)[CH:12]=2)=[CH:4][CH:3]=1.Cl[C:21]1[CH:26]=[C:25]([C:27]2[CH:28]=[CH:29][C:30]([O:35][CH:36]3[CH2:41][CH2:40][O:39][CH2:38][CH2:37]3)=[C:31]([CH:34]=2)[C:32]#[N:33])[CH:24]=[CH:23][N:22]=1>>[NH:11]1[CH:12]=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([NH:1][C:23]3[CH:24]=[C:25]([C:27]4[CH:28]=[CH:29][C:30]([O:35][CH:36]5[CH2:41][CH2:40][O:39][CH2:38][CH2:37]5)=[C:31]([CH:34]=4)[C:32]#[N:33])[CH:26]=[CH:21][N:22]=3)=[N:7][CH:6]=2)[CH:9]=[N:10]1

Participants

3

Reactant 2

HCID 86729187HCID 86729187, compoundHCID 86729188HCID 86729188, compound

Product 1

HCID 71295260HCID 71295260, compoundYield 16%

Procedure

85 mg of tert-butyl 4-(6-aminopyridin-3-yl)pyrazole-1-carboxylate are reacted with 100 mg of 5-(2-chloropyridin-4-yl)-2-(tetrahydropyran-4-yloxy)benzonitrile in accordance with the above-mentioned general procedure for the Buchwald-Hartwig reaction, giving the desired product in 16% yield;

Sources & evidence

ORD record
ord-22ae0a203cc74eaa9a0ca212e018f31e
Source dataset
uspto-grants-2015_03
Patent number
US08969335B2

Reaction notes

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