HCID 71511094, compound → HCID 71295246, compound

HRID 868817Notes

Reaction equation

HRID 868817 reaction equation
[NH:1]1[CH:5]=[C:4]([NH:6][C:7]2[N:12]=[C:11]([C:13]3[CH:14]=[CH:15][C:16]([O:21][CH:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)=[C:17]([CH:20]=3)[C:18]#[N:19])[CH:10]=[CH:9][N:8]=2)[CH:3]=[N:2]1>C(#N)C>[CH3:22][O:21][CH2:16][CH2:15][N:1]1[CH:5]=[C:4]([NH:6][C:7]2[N:12]=[C:11]([C:13]3[CH:14]=[CH:15][C:16]([O:21][CH:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)=[C:17]([CH:20]=3)[C:18]#[N:19])[CH:10]=[CH:9][N:8]=2)[CH:3]=[N:2]1

Participants

3

Reactant 1

HCID 71511094HCID 71511094, compound

Product 1

HCID 71295246HCID 71295246, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
90 °C

Procedure

16 mg of 5-[2-(1H-pyrazol-4-ylamino)pyrimidin-4-yl]-2-(tetrahydropyran-4-yloxy)benzonitrile are dissolved in 1 ml of dried acetonitrile in a 50 ml flask provided with magnetic stirrer, condenser and drying tube, 9 mg of bromoethyl methyl ether and 28 mg of Cs2CO3 are added, and the suspension is stirred at a bath temperature of 90° C. The reaction mixture is stirred at 90° C. for 5 hours and at room temperature overnight.

Workup

  1. customprovided with magnetic stirrer, condenser
  2. customdrying tube
  3. addition9 mg of bromoethyl methyl ether and 28 mg of Cs2CO3 are added
  4. stirringThe reaction mixture is stirred at 90° C. for 5 hours and at room temperature overnight

Sources & evidence

ORD record
ord-a12d92d075d14cd5b009b561f29668b5
Source dataset
uspto-grants-2015_03
Patent number
US08969335B2

Reaction notes

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