HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-bromoisonicotinate → 3-[(5-trifluoromethyl-1-methyl-1H-indazol-3-yl)amino]pyridine-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-bromoisonicotinate | HCID 2762700 | — |
| Reactant | 1-Methyl-5-(trifluoromethyl)-1H-indazol-3-amine | HCID 28875377 | — |
| Product | 3-[(5-trifluoromethyl-1-methyl-1H-indazol-3-yl)amino]pyridine-4-carboxylic acid | HCID 76282292 | 44% |
Reaction Steps
The title compound was prepared in 44% yield from methyl 3-bromoisonicotinate and 3-amino-5-trifluoromethyl-1-methyl-indazole according to the general procedure for Example 6. 1H NMR (400 MHz, DMSO-d6): δ 4.05 (3H, s), 7.72-7.83 (3H, m), 7.99 (1H, s), 8.21 (1H, d, J=5.0 Hz), 9.64 (1H, s), 10.69 (1H, br s), 14.12 (1H, br s). [M+H] calc'd for C15H11F3N4O2, 337; found 337.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969343B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-a596b1af37c04cf8b1e59e8cd763b29c |
| Source note | uspto-grants-2015_03 |