Benzyl Bromide → 1-benzyl-5-fluoro-3-iodo-1H-indazole

HRID 868853Notes

Reaction equation

HRID 868853 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[I:11].[CH2:12](Br)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([N:7]1[C:8]2[C:4](=[CH:3][C:2]([F:1])=[CH:10][CH:9]=2)[C:5]([I:11])=[N:6]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 178505475HCID 178505475, compound

Product 1

HCID 867231431-benzyl-5-fluoro-3-iodo-1H-indazoleYield 75%

Procedure

The title compound was prepared in 75% yield from 5-fluoro-3-iodo-indazole and benzyl bromide according to the general procedure for Preparation 10A. The minor isomer was not isolated or characterized. 1H NMR (400 MHz, CDCl3): δ 5.59 (2H, s), 7.11-7.21 (5H, m), 7.23-7.31 (3H, m).

Workup

  1. customThe minor isomer was not isolated

Sources & evidence

ORD record
ord-f70d12814ffb4b8894c45f1dd3a8856a
Source dataset
uspto-grants-2015_03
Patent number
US08969343B2

Reaction notes

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