Bromomethylcyclopropane → HCID 86723150, compound

HRID 868860Notes

Reaction equation

HRID 868860 reaction equation
[I:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:11])[CH:9]=2)[NH:4][N:3]=1.Br[CH2:13][CH:14]1[CH2:16][CH2:15]1>>[CH:14]1([CH2:13][N:4]2[C:5]3[C:10](=[CH:9][C:8]([CH3:11])=[CH:7][CH:6]=3)[C:2]([I:1])=[N:3]2)[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 178423510HCID 178423510, compound

Product 1

HCID 86723150HCID 86723150, compoundYield 66%

Procedure

The title compound was prepared in 66% yield from 3-iodo-5-methyl-indazole and (bromomethyl)cyclopropane according to the general procedure for Preparation 10A. The minor isomer was not isolated or characterized. 1H NMR (400 MHz, CDCl3): δ 0.38-0.41 (2H, m), 0.54-0.59 (2H, m), 1.31-1.34 (1H, s), 2.48 (3H, s), 4.24 (2H, d, J=7.2 Hz), 7.23-7.29 (3H, m).

Workup

  1. customThe minor isomer was not isolated

Sources & evidence

ORD record
ord-57f651e235974014bfbf89f4dd63a93a
Source dataset
uspto-grants-2015_03
Patent number
US08969343B2

Reaction notes

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