Tetrahydro-4H-pyran-4-ol → HCID 86723167, compound

HRID 868879Notes

Reaction equation

HRID 868879 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[I:11].[O:12]1[CH2:17][CH2:16][CH:15](O)[CH2:14][CH2:13]1>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH:15]1[CH2:16][CH2:17][O:12][CH2:13][CH2:14]1)[N:6]=[C:5]2[I:11]

Participants

3

Reactant 2

HCID 74956Tetrahydro-4H-pyran-4-olHCID 178505475HCID 178505475, compound

Product 1

HCID 86723167HCID 86723167, compoundYield 56%

Procedure

The title compound was prepared from 5-fluoro-3-iodo-indazole and tetrahydro-4-pyranol in 56% yield according to the general procedure for Preparation 31A. The minor isomer was not isolated or characterized.

Workup

  1. customThe minor isomer was not isolated

Sources & evidence

ORD record
ord-f23c5856fd07416cb06878a6e9ad5747
Source dataset
uspto-grants-2015_03
Patent number
US08969343B2

Reaction notes

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