1-(2-Chloroethyl)pyrrolidine hydrochloride → HCID 86723173, compound

HRID 868887Notes

Reaction equation

HRID 868887 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[I:11].Cl.Cl[CH2:14][CH2:15][N:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:14][CH2:15][N:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1)[N:6]=[C:5]2[I:11]

Participants

3

Reactant 2

HCID 816681-(2-Chloroethyl)pyrrolidine hydrochlorideHCID 178477912HCID 178477912, compound

Product 1

HCID 86723173HCID 86723173, compoundYield 60%

Procedure

The title compound was prepared from 5-chloro-3-iodo-indazole and 1-(2-chloroethyl)pyrrolidine hydrochloride in 60% yield according to the procedure for Preparation 50A. 1H NMR (400 MHz, CDCl3): δ 1.75-1.80 (4H, m), 2.54-2.59 (4H, m), 2.99 (2H, t, J=7.3 Hz), 4.52 (2H, t, J=7.1 Hz), 7.35-7.39 (2H, m), 7.45 (1H, s). [M+H] Calc'd for C13H15ClN3, 376; Found, 376.

Sources & evidence

ORD record
ord-305f3075c7fd4847972841720196f3e6
Source dataset
uspto-grants-2015_03
Patent number
US08969343B2

Reaction notes

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