HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → ((1-Oxo-1,2-dihydroisoquinolin-3-yl)methyl)triphenylphosphonium bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 3-(Bromomethyl)isoquinolin-1(2H)-one | HCID 70097212 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | ((1-Oxo-1,2-dihydroisoquinolin-3-yl)methyl)triphenylphosphonium bromide | HCID 86687889 | — |
Reaction Steps
A solution of 3-(bromomethyl)isoquinolin-1(2H)-one and PPh3 (1.8 g, 6.87 mmol) in 1,4-dioxane (50 mL) was refluxed for 2 h. After cooling to room temperature, the reaction mixture was filtered to give the desired product (317 mg). LC-MS: m/z 420 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969349B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-e03deec29a774059a8178d29caafce31 |
| Source note | uspto-grants-2015_03 |