HCID 70648558, compound → HCID 70098706, compound

HRID 868913Notes

Reaction equation

HRID 868913 reaction equation
[CH3:1][N:2]([CH3:31])[S:3]([N:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:8]=[C:7]1[CH2:17][CH2:18][C:19]([NH:21][C:22]1[CH:30]=[CH:29][CH:28]=[CH:27][C:23]=1[C:24](O)=[O:25])=[O:20])(=[O:5])=[O:4]>CC(OC(C)=O)=O>[CH3:1][N:2]([CH3:31])[S:3]([N:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:8]=[C:7]1[CH2:17][CH2:18][C:19]1[O:20][C:24](=[O:25])[C:23]2[CH:27]=[CH:28][CH:29]=[CH:30][C:22]=2[N:21]=1)(=[O:4])=[O:5]

Participants

3

Reactant 1

HCID 70648558HCID 70648558, compound

Product 1

HCID 70098706HCID 70098706, compoundYield 69.5%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A solution of 2-(3-(1-(N,N-dimethylsulfamoyl)-4-phenyl-1H-imidazol-2-yl)propanamido)benzoic acid (150 mg, 0.339 mmol) in Ac2O (10 mL) was stirred at reflux for 5 h. The reaction mixture was then concentrated to give a white solid (100 mg), which was used for the next step without further purification. LC-MS: m/z 425 (M+H+).

Workup

  1. temperatureat reflux for 5 h
  2. concentrationThe reaction mixture was then concentrated

Sources & evidence

ORD record
ord-948a8bcbccd14c54bf51cddbb291fd31
Source dataset
uspto-grants-2015_03
Patent number
US08969349B2

Reaction notes

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