反应详情

A mixture of benzoin (2.65 g, 12.5 mmol), formamide (10 mL), xylene (40 mL) and conc. H2SO4 (1 mL) was refluxed for 14 h with a dean-stark trap attached to remove water. After cooling to room temperature, water was added to the mixture. The organic layer was separated, washed, dried (with MgSO4), and then distilled under reduced pressure to give 4,5-diphenyloxazole (1.93 g) as a yellow solid.

1. temperaturewas refluxed for 14 h with a dean-stark trap
2. customto remove water
3. additionwater was added to the mixture
4. customThe organic layer was separated
5. washwashed
6. dry with materialdried (with MgSO4)
7. distillationdistilled under reduced pressure