反应详情

温度

90 °C

A mixture of 2,5-dimethylpyridine (12.5 g, 0.12 mol) and 30% hydrogen peroxide (30 mL) in acetic acid (25 mL) was stirred at 90° C. for 48 h. The reaction mixture was diluted with water (50 mL) and concentrated to a volume of approximately 25 mL. The concentrated solution was neutralized with solid sodium carbonate, extracted with DCM (100 mL×3), dried with anhydrous sodium sulfate, and concentrated to give 14.4 g of the product as a yellow oil. MS (ESI): m/z 124.1 [M+H]+.

1. concentrationconcentrated to a volume of approximately 25 mL
2. extractionextracted with DCM (100 mL×3)
3. dry with materialdried with anhydrous sodium sulfate
4. concentrationconcentrated