反应详情

温度

80 °C

To a solution of 5-chloro-1,6-naphthyridine (3.3 g, 20.1 mmol) in DMF (40 mL) was added sodium azide (6.0 g, 88.5 mmol). The mixture was stirred at 80° C. overnight. The mixture was poured into water (120 mL). The aqueous phase was extracted with EtOAc (150 mL×4). The combined organic layers were washed with brine (100 mL×3), dried over sodium sulfate, and concentrated under reduced pressure to give 3.4 g of the crude product as a brown solid. MS (ESI): m/z 172 [M+H]+.

1. extractionThe aqueous phase was extracted with EtOAc (150 mL×4)
2. washThe combined organic layers were washed with brine (100 mL×3)
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated under reduced pressure