Acetyl chloride → HCID 53497003, compound

HRID 869136Notes

Reaction equation

HRID 869136 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:28])([CH3:27])[CH2:9][NH:10][C:11]2[N:16]=[N:15][C:14]([C:17]3[CH:18]=[C:19]4[C:23](=[CH:24][CH:25]=3)[NH:22][N:21]=[C:20]4[NH2:26])=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.[C:29](Cl)(=[O:31])[CH3:30]>N1C=CC=CC=1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:28])([CH3:27])[CH2:9][NH:10][C:11]2[N:16]=[N:15][C:14]([C:17]3[CH:18]=[C:19]4[C:23](=[CH:24][CH:25]=3)[NH:22][N:21]=[C:20]4[NH:26][C:29](=[O:31])[CH3:30])=[CH:13][CH:12]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 67454622HCID 67454622, compound

Product 1

HCID 53497003HCID 53497003, compoundYield 44.9%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 5-(6-(2-(4-fluorophenyl)-2-methylpropylamino)pyridazin-3-yl)-1H-indazol-3-amine (50 mg, 133 μmol) in pyridine (1 mL) was added acetyl chloride (9.5 μL, 133 μmol). The mixture was stirred for 15 min, concentrated, purified by reverse phase chromatography using a CH3CN/water gradient to afford 25 mg of white solid, m/z=419.9 [M+H].

Workup

  1. concentrationconcentrated
  2. custompurified by reverse phase chromatography

Sources & evidence

ORD record
ord-93106ba669e347929af0ac6d588ee634
Source dataset
uspto-grants-2015_03
Patent number
US08969346B2

Reaction notes

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