1,4-Dioxane hydrochloride → HCID 66642971, compound

HRID 869225Notes

Reaction equation

HRID 869225 reaction equation
[CH2:1]([C:3]1([OH:17])[CH2:8][CH2:7][CH:6]([NH:9]C(=O)OC(C)(C)C)[CH2:5][CH2:4]1)[CH3:2].[ClH:18].O1CCOCC1>O1CCOCC1>[ClH:18].[NH2:9][CH:6]1[CH2:7][CH2:8][C:3]([CH2:1][CH3:2])([OH:17])[CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 68041885HCID 68041885, compound

Product 1

HCID 66642971HCID 66642971, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a mixture of tert-butyl (4-ethyl-4-hydroxycyclohexyl)carbamate (Preparation Example 248) (0.256 g) and dioxane (2 mL), 26% hydrogen chloride-dioxane (1.4 mL) was added under ice cooling and stirred at room temperature for 17 hours. The precipitated solid was collected by filtration to give 4-amino-1-ethylcyclohexanol hydrochloride (0.152 g) as a white solid.

Workup

  1. additionwas added under ice cooling
  2. filtrationThe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-e01c98c13e754067a519bbecd58ac897
Source dataset
uspto-grants-2015_03
Patent number
US08969336B2

Reaction notes

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