1,4-Dioxane hydrochloride → HCID 66642971, compound

Participants

Reaction Steps

To a mixture of tert-butyl (4-ethyl-4-hydroxycyclohexyl)carbamate (Preparation Example 248) (0.256 g) and dioxane (2 mL), 26% hydrogen chloride-dioxane (1.4 mL) was added under ice cooling and stirred at room temperature for 17 hours. The precipitated solid was collected by filtration to give 4-amino-1-ethylcyclohexanol hydrochloride (0.152 g) as a white solid.

Provenance & Evidence